Age-Rev TeloNAD⁺

Age-Rev TeloNAD⁺ is a two-blend delayed-release capsule formulation targeting cellular aging through complementary NAD⁺ and polyphenol pathways.

VITAMINS: Vitamin B6 (as pyridoxine HCl) — methylation cofactor; supports the one-carbon cycle essential for NAD⁺ metabolism and neurotransmitter synthesis. Vitamin B12 (as methylcobalamin) — active form of B12; direct methyl donor supporting homocysteine recycling.

NAD⁺ & METHYLATION BOOSTER-BLEND: Nicotinamide Riboside (NR) — direct NAD⁺ precursor via the salvage pathway; published human studies showing NAD⁺ level increases. Glycine — amino acid supporting collagen synthesis, glutathione production, and the one-carbon methylation cycle. β-Nicotinamide Adenine Dinucleotide (NAD⁺) — direct NAD⁺ supplementation; helps support sirtuin activation and cellular energy. Trimethylglycine (TMG/Betaine) — methyl donor supporting the methionine cycle that NAD⁺ metabolism depends on; prevents methyl depletion. Nicotinamide Mononucleotide (NMN) — NAD⁺ precursor complementary to NR; enters the salvage pathway at a different point. Calcium α-ketoglutarate (Ca-AKG) — TCA-cycle substrate; published associations with biological age markers (Rejuvant study); supports mitochondrial energy.

SENESCENCE-DEFENCE POLYPHENOL BLEND: Micronized Trans-Resveratrol — sirtuin/AMPK activator; helps support cellular vitality signalling; micronized for enhanced absorption. Micronized Astragalus root extract — traditional adaptogen; contains cycloastragenol precursors; published associations with telomere support. Micronized Gotu Kola aerial extract — traditional longevity herb; helps support collagen synthesis and tissue integrity; triterpenoid saponins. Micronized Cycloastragenol — telomere-supportive botanical; helps support telomerase activity and cellular replication fidelity.

OTHER INGREDIENTS: Delayed-release capsule (Hypromellose, Gellan gum, Yellow iron oxide), Polysorbate 80, Colloidal Silicon Dioxide, Stearic Acid, Maltodextrin.

MICRONIZED POLYPHENOLS: Trans-resveratrol has notoriously poor oral bioavailability (<1% in standard form) due to rapid glucuronidation and sulfation. Micro Matrix micronization increases surface area for faster dissolution and the matrix composition modulates Phase II metabolism to extend systemic presence.

MICRONIZED CYCLOASTRAGENOL: This rare compound is typically available only in microgram quantities from astragalus extraction. Micronization ensures maximum surface area for absorption of this low-dose, high-value active.

DELAYED-RELEASE PROTECTION: NAD⁺ and NMN are sensitive to stomach acid degradation. The delayed-release capsule (Hypromellose + Gellan gum) protects these acid-sensitive precursors, releasing them in the small intestine where absorption is optimal and degradation is minimised.

SELF-EMULSIFYING MATRIX: The polysorbate 80 + maltodextrin + stearic acid matrix creates spontaneous micelle formation for the lipophilic polyphenols (resveratrol, cycloastragenol), presenting them in a bioavailable form at the intestinal epithelium.

Key takeaway: Without Micro Matrix Technology, most of the polyphenol blend would be destroyed by first-pass metabolism before reaching systemic circulation. The combination of micronization, matrix protection, and delayed release is what makes a multi-ingredient longevity formula viable rather than theoretical.

PATHWAY 1 — NAD⁺ REPLENISHMENT: NAD⁺ levels decline approximately 50% between ages 40–60. This decline is associated with reduced sirtuin activity, impaired DNA repair, and mitochondrial dysfunction. Age-Rev provides THREE NAD⁺ sources (NR, NMN, and direct NAD⁺) to support replenishment through multiple salvage pathways simultaneously — hedging against individual pathway limitations.

PATHWAY 2 — METHYLATION SUPPORT: NAD⁺ metabolism consumes methyl groups. Without adequate methylation support, NAD⁺ supplementation can deplete the methyl pool — potentially worsening homocysteine levels and epigenetic methylation patterns. TMG (Betaine) and B6/B12 provide methyl donors to prevent this depletion. This is a design consideration often missed by single-ingredient NAD⁺ products.

PATHWAY 3 — SIRTUIN & AMPK ACTIVATION: Trans-Resveratrol activates SIRT1 and AMPK pathways. These master regulators influence cellular autophagy (self-cleaning), mitochondrial biogenesis (new mitochondria production), and inflammatory signalling. NAD⁺ is the essential cofactor for sirtuin activity — so NAD⁺ replenishment + sirtuin activation work synergistically.

PATHWAY 4 — TELOMERE & SENESCENCE SUPPORT: Cycloastragenol has published associations with telomerase activity support. Astragalus provides additional triterpenoid saponins. Gotu Kola supports collagen and connective tissue integrity. Calcium α-ketoglutarate has published associations with biological age markers. Together these address cellular replication fidelity and senescent cell accumulation.

SYNERGISTIC DESIGN: The four pathways are not independent — they form a reinforcing loop. NAD⁺ enables sirtuin activity. Sirtuins promote autophagy (clearing senescent cells). Methylation support prevents NAD⁺ supplementation from causing downstream problems. Polyphenols activate the same pathways that NAD⁺ enables. The whole is greater than the sum of parts.

NICOTINAMIDE RIBOSIDE (NR): Multiple published human studies. Trammell et al. (2016): NR supplementation increases NAD⁺ levels in humans. Martens et al. (2018): NR supplementation associated with reduced blood pressure and aortic stiffness in older adults. Mechanism: enters NAD⁺ salvage pathway via NR kinase.

NMN (NICOTINAMIDE MONONUCLEOTIDE): Emerging human clinical data. Yoshino et al. (2021): NMN improves muscle insulin sensitivity in prediabetic women. Multiple ongoing human trials. Mechanism: direct NAD⁺ precursor one step closer to NAD⁺ than NR.

TRANS-RESVERATROL: Extensive published literature. Timmers et al. (2011): resveratrol induces metabolic changes mimicking caloric restriction in obese humans. Mechanism: SIRT1/AMPK activation, anti-inflammatory signalling. Note: bioavailability is the key challenge — Micro Matrix micronization addresses this.

CYCLOASTRAGENOL: Limited but growing evidence. Harley et al. (2011): TA-65 (cycloastragenol-based) associated with telomere length maintenance. Mechanism: telomerase activation support. Note: this is the most preliminary evidence in the formula — position carefully.

CALCIUM α-KETOGLUTARATE: Demidenko et al. (2021 — Rejuvant study): Ca-AKG supplementation associated with reduction in biological age markers. Mechanism: TCA cycle substrate, epigenetic modulation via α-KG-dependent dioxygenases.

Important: Each ingredient has individual published evidence at various levels. However, the complete Age-Rev TeloNAD⁺ formula has NOT been tested as a whole in a human clinical trial. The multi-pathway approach is a formulation rationale based on complementary mechanisms, not a clinically proven synergy.

APPROVED CLAIMS: 'Supports healthy aging at the cellular level' | 'Designed to support NAD⁺ levels' | 'Contains ingredients that may help support cellular energy' | 'Formulated with Micro Matrix Technology for enhanced polyphenol delivery' | 'Contains B vitamins that contribute to normal energy-yielding metabolism' | 'Multi-pathway approach to cellular vitality' | 'Contains clinically studied NAD⁺ precursors'

PROHIBITED CLAIMS: 'Reverses aging' | 'Extends lifespan' | 'Treats any age-related disease' | 'Prevents cellular senescence' | 'FDA approved' | 'Guaranteed anti-aging results' | 'Equivalent to prescription therapies' | 'Turns back the clock' | 'Makes you younger' | 'Proven to lengthen telomeres' | 'Anti-aging miracle'

NUANCED POSITIONING: You CAN say: 'Age-Rev TeloNAD⁺ provides NAD⁺ precursors, methylation support, and senescence-defence polyphenols — addressing multiple cellular aging pathways in one formula.' You CANNOT say: 'Age-Rev reverses aging' or 'makes you biologically younger.'

TELOMERE CLAIMS: Be especially careful with telomere language. 'Contains cycloastragenol, which has published associations with telomere support' is acceptable. 'Lengthens your telomeres' or 'prevents aging by protecting telomeres' is NOT acceptable — the evidence is preliminary and individual.

Key takeaway: Age-Rev TeloNAD⁺ supports cellular processes associated with healthy aging. It does NOT reverse aging, extend lifespan, or treat age-related diseases. The multi-pathway NAD⁺ approach + methylation support is the key differentiator vs single-ingredient NR or NMN products.

Required FDA Disclaimer: 'These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.'